Understanding how genetic conflicts shape evolution
Official title: Molecular mechanisms of genomic conflicts and hybrid incompatibilities
Funded at University of Utah · NIH-11012176 · Data updated 2026-11-12
This study is looking at how certain selfish genes in fruit flies can cause problems when different species try to mix, which might help us understand genetic issues in humans and lead to better medical treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $423,500 |
| NIH project number | 1R35GM156267-01 |
| Project ID | NIH-11012176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit would include individuals with genetic disorders or those interested in the implications of evolutionary biology on health.
✕Less likely to help
Patients with conditions unrelated to genetic mechanisms or evolutionary biology may not receive direct benefits from this research.
What this research studies
This research investigates the genetic and molecular mechanisms behind evolutionary conflicts, particularly focusing on how selfish genetic elements can influence the evolution of genomes and species. By studying Drosophila, a type of fruit fly, the research aims to uncover the reasons behind hybrid incompatibilities and the rapid evolution of cellular machinery. The approach includes examining cell cycle checkpoints and DNA replication processes to understand hybrid lethality and sterility. Patients may benefit from insights into genetic disorders and evolutionary biology that could inform future medical advancements.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic disorders and lead to new therapeutic strategies.
How similar studies have gone: While this research explores novel aspects of genetic conflicts, similar studies have shown success in understanding evolutionary mechanisms in other species.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Phadnis, Nitin — University of Utah
- Study coordinator: Phadnis, Nitin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.