Understanding how genetic changes make prostate cancer aggressive
Investigating the impact of chromosomal instability on prostate cancer aggressiveness
This research explores why some prostate cancers become very aggressive and spread, focusing on how unstable chromosomes contribute to this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11132977 on NIH RePORTER |
What this research studies
Prostate cancer can become incurable once it spreads, and we don't fully understand why some cancers become so aggressive. This project looks at how changes in chromosomes, called chromosomal instability (CIN), help prostate cancer cells survive and grow. We are using advanced tools to find out how CIN changes the way cancer cells work and how a specific protein, MASTL, helps these unstable cells. The goal is to uncover new ways to stop aggressive prostate cancer.
Who could benefit from this research
Good fit: This foundational research is for patients with aggressive or metastatic prostate cancer, as it aims to understand the underlying biology of their disease.
Not a fit: Patients with early-stage, non-aggressive prostate cancer may not directly benefit from this specific research focus on advanced disease mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for aggressive, metastatic prostate cancer by targeting the mechanisms that allow it to become lethal.
How similar studies have performed: Other studies have also linked chromosomal instability to aggressive cancers, and this work builds on previous findings that show its role in prostate cancer survival.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Rodriguez-Bravo, Veronica — Mayo Clinic Rochester
- Study coordinator: Rodriguez-Bravo, Veronica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.