Understanding how genetic changes lead to new traits and structures in organisms
The Genetic and Epigenetic Mechanisms of Phenotypic Innovation
This study is exploring how tiny changes in genes help create new traits in fruit flies, which can teach us more about how different forms of life evolve and develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10765410 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic mechanisms that contribute to the development of new traits and structures in organisms, particularly focusing on Drosophila. By examining novel regulatory sequences and elements, the study aims to uncover how new genes are expressed and how these changes influence evolution. The approach includes advanced techniques like single-cell RNA sequencing and ATAC sequencing to identify key enhancers and promoters involved in gene regulation. This research seeks to deepen our understanding of the complexity of life and the origins of morphological diversity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or developmental issues related to morphological traits.
Not a fit: Patients with established genetic conditions that are not related to the mechanisms being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic disorders and developmental diseases, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success in understanding genetic mechanisms of evolution, but this specific approach focusing on novel regulatory sequences is relatively novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Zhao, Li — Rockefeller University
- Study coordinator: Zhao, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.