Understanding how genetic changes in tuberculosis bacteria affect drug responses
Establishing the Genetic Basis of Altered Drug Responses in Mycobacterium tuberculosis
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-10595538
This study is looking at how some genetic changes in tuberculosis bacteria might cause treatment to not work, even when the bacteria seem like they should respond to the medicine, and it's for patients who want to understand why their treatment might not be effective.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10595538 on ClinicalTrials.gov |
What this research studies
This research investigates how certain genetic mutations in Mycobacterium tuberculosis may lead to treatment failures in patients, even when the bacteria appear drug-susceptible. By analyzing bacterial responses to antibiotics under conditions that mimic the human body, the researchers aim to identify mutations that contribute to both drug resistance and treatment failure. The study will involve creating a library of bacterial strains with specific mutations to observe their behavior in the presence of antibiotics, using mouse models to simulate human infection scenarios.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with tuberculosis who have experienced treatment failures or have drug-resistant strains of the bacteria.
Not a fit: Patients with non-tuberculosis infections or those who have not been diagnosed with tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for tuberculosis, reducing the risk of treatment failure and enhancing patient outcomes.
How similar studies have performed: Previous research has shown that understanding genetic mutations in bacteria can lead to significant advancements in treatment approaches, suggesting a promising avenue for this study.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FORTUNE, SARAH — HARVARD MEDICAL SCHOOL
- Study coordinator: FORTUNE, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.