Understanding how genetic changes in T-cells affect cancer treatment outcomes
Functional epigenomics of transgenic cellular immunotherapies for cancer
This study is looking at how special immune cells called T-cells change over time in cancer patients who have received T-cell therapy, to help understand why some people do better with the treatment than others and find ways to make it work even better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11014376 on NIH RePORTER |
What this research studies
This research investigates the changes in genetic and functional characteristics of T-cells that are engineered to fight cancer over time. By analyzing samples from patients who have undergone T-cell therapy, the study aims to identify how these changes relate to the effectiveness of the treatment. The research will focus on understanding the reasons why some patients respond well to therapy while others do not, and how the T-cells' ability to function may decline. This could lead to improved strategies for enhancing the effectiveness of cancer immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing T-cell therapy for cancer who may experience varying responses to treatment.
Not a fit: Patients who are not receiving T-cell therapy or those with cancers not treated by this approach may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying ways to maintain T-cell function over time.
How similar studies have performed: Previous research has shown promising results in understanding T-cell behavior in cancer therapies, indicating that this approach has potential for significant advancements.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Nowicki, Theodore Scott — University of California Los Angeles
- Study coordinator: Nowicki, Theodore Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.