Understanding how genetic changes in single cells lead to abnormal cell growth
Single-Cell Multi-omics to Link Clonal Mosaicism (CM) Genotypes with Chromatin, Epigenomic, Transcriptomic and Protein Phenotypes
This project aims to understand how small genetic changes in individual cells in normal human tissues can lead to cells growing abnormally, potentially contributing to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11134506 on NIH RePORTER |
What this research studies
Our bodies naturally develop small groups of cells with genetic changes, called clonal outgrowths, which can sometimes contain mutations linked to cancer. We don't fully understand how these specific genetic changes allow these cells to grow and outcompete normal cells. To learn more, we've developed advanced tools that can look at many different types of information—like genes, proteins, and cell activity—from a single cell. This allows us to compare cells with these genetic changes directly to normal cells from the same person. By doing this, we hope to uncover the exact ways these mutations give cells a growth advantage.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future studies building on this work may seek individuals with or at risk for conditions involving clonal mosaicism.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to a better understanding of how diseases like cancer begin, potentially helping to identify new ways to prevent or treat them early.
How similar studies have performed: While single-cell technologies are rapidly advancing, this project aims to extend a novel multi-omic toolkit to specifically link somatic mutations to clonal growth advantage in human tissues.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Landau, Dan — Weill Medical Coll of Cornell Univ
- Study coordinator: Landau, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.