Understanding how genetic changes in PLCG2 affect Alzheimer's disease risk
Official title: Deciphering genetics of PLCG2 alternative splicing to understand AD risk
Funded at University of Kentucky · NIH-10889353 · Data updated 2026-11-12
This study is looking at how changes in a specific gene called PLCG2 might affect the risk of developing Alzheimer's disease, with the hope that understanding these genetic factors can help create better treatments for people at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $415,626 |
| NIH project number | 1R21AG083820-01A1 |
| Project ID | NIH-10889353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who have been genetically tested and identified as having risk variants associated with AD.
✕Less likely to help
Patients who do not have a genetic predisposition to Alzheimer's disease or those with other forms of dementia unrelated to the genetic factors being studied may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence the risk of developing Alzheimer's disease (AD), focusing specifically on the PLCG2 gene. The study aims to understand how variations in this gene affect its expression and splicing, which may play a crucial role in AD pathology. By examining genetic variants and their impact on PLCG2, researchers hope to uncover new insights into the molecular mechanisms of AD. This could lead to the development of targeted therapies that address these genetic influences.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting specific genetic mechanisms.
How similar studies have gone: Other research has shown success in identifying genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Estus, Steven — University of Kentucky
- Study coordinator: Estus, Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.