Understanding how genetic changes in cells increase with age
GENETIC HETEROGENEITY AMONG HUMAN SOMATIC CELLS AND ITS ACCUMULATION WITH AGE
This study is looking at how tiny changes in our genes build up in healthy cells as we get older, which might raise the chances of getting cancer or other age-related diseases, and it's specifically examining colon cells to learn more about these changes in people of different ages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10657814 on NIH RePORTER |
What this research studies
This research investigates how genetic mutations accumulate in normal tissues as people age, which may increase the risk of cancer and contribute to various degenerative diseases. By analyzing colon cells, the researchers aim to identify and compare the genetic sequences of individual cells to better understand these mutations. The study utilizes advanced sequencing techniques to examine both nuclear and mitochondrial genomes, focusing on how these changes differ among individuals of various ages. This could lead to insights into the biological processes of aging and disease development.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those interested in the genetic factors related to aging and associated diseases.
Not a fit: Patients under the age of 21 or those without concerns related to aging or genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for age-related diseases and cancers.
How similar studies have performed: Previous research has shown promising results in understanding genetic mutations related to aging, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsieh, Chih-Lin — University of Southern California
- Study coordinator: Hsieh, Chih-Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.