Understanding how genetic changes in C. elegans affect adaptation and behavior
Identification and study of adaptive mutations and phenotypes using laboratory growth of C. elegans
['FUNDING_OTHER'] · GEORGIA INSTITUTE OF TECHNOLOGY · NIH-11002288
This study is looking at how tiny worms called C. elegans adapt to their surroundings by exploring the genetic changes that help them thrive, especially in how they communicate and manage their genes, so we can better understand how living things adjust to new challenges.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11002288 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic basis of adaptation using the model organism C. elegans, a small nematode. By studying how genetic mutations influence traits related to development, behavior, and metabolism, the researchers aim to uncover the mechanisms that enhance fitness in changing environments. The project will focus on identifying genetic changes that affect pheromone signaling and the evolution of chromatin remodeling, which plays a crucial role in gene expression. Through laboratory growth and experimental evolution, the research seeks to provide insights into how these genetic adaptations occur.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic conditions related to development, metabolism, or cancer progression.
Not a fit: Patients with conditions unrelated to genetic mutations or those not affected by metabolic or developmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors that influence human diseases and adaptations, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success in using model organisms like C. elegans to study genetic adaptations, making this approach both validated and promising.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA INSTITUTE OF TECHNOLOGY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCGRATH, PATRICK T — GEORGIA INSTITUTE OF TECHNOLOGY
- Study coordinator: MCGRATH, PATRICK T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer progression, Cancers