Understanding how genetic changes in body tissues affect health and disease
Official title: WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center
Funded at Washington University · NIH-11098566 · Data updated 2026-11-12
This study is looking at how changes in our genes can affect our health and aims to help researchers work together better, so they can find new ways to understand and treat different health conditions that might be linked to these gene changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,494,273 |
| NIH project number | 5U24NS132103-03 |
| Project ID | NIH-11098566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with genetic disorders or those interested in the implications of somatic mosaicism in their health.
✕Less likely to help
Patients with conditions unrelated to genetic variations in somatic tissues may not receive direct benefits from this research.
What this research studies
The SMaHT Network focuses on discovering new biological processes related to genomic variations in human tissues. This research aims to enhance the coordination and sharing of genomic data to better understand how these variations influence health and disease. By establishing a central organizational center, the project will facilitate collaboration among researchers and improve access to valuable genomic resources. Patients may benefit from insights gained about the role of somatic mosaicism in various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights into disease mechanisms and potential therapeutic targets for various health conditions.
How similar studies have gone: Previous research initiatives in genomic data sharing and analysis have shown promise, suggesting that this approach could yield significant advancements in understanding human health.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Wang, Ting — Washington University
- Study coordinator: Wang, Ting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.