Understanding how genetic changes in blood cells relate to various diseases
Official title: Multi-omic dissection of clonal hematopoiesis-associated diseases
Funded at Massachusetts General Hospital · NIH-11165567 · Data updated 2026-11-12
This study is looking at how changes in blood stem cells, which can happen as we age or due to our environment, might be connected to diseases like heart disease and stroke, and it hopes to find ways to help prevent and treat these conditions for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HG012956-02 |
| Project ID | NIH-11165567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who may have conditions related to clonal hematopoiesis, such as coronary artery disease or stroke.
✕Less likely to help
Patients with no history of blood-related diseases or those under 21 years old may not receive benefits from this research.
What this research studies
This research investigates how certain genetic mutations in blood stem cells, which can accumulate over time due to aging or environmental factors, may lead to various diseases such as heart disease and stroke. By analyzing complex biological data from large health databases, the study aims to uncover the molecular mechanisms linking these mutations to specific health conditions. Patients may benefit from insights that could lead to better prevention and treatment strategies for diseases associated with clonal hematopoiesis.
Why it matters
Potential benefit: If successful, this research could provide critical insights into preventing and treating diseases linked to genetic changes in blood cells.
How similar studies have gone: Previous research has shown promising results in understanding the links between genetic mutations and various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Yu, Zhi — Massachusetts General Hospital
- Study coordinator: Yu, Zhi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.