Understanding how genetic changes in Alzheimer's disease interact within cells
Alzheimer variants: Propagation of shared functional changes across cellular networks
This study is looking at how different genes work together to affect Alzheimer's disease, and it's for anyone interested in understanding more about the genetic factors that might influence the condition, with the hope that it could lead to better insights and treatments for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10872331 on NIH RePORTER |
What this research studies
This research investigates the complex genetic factors contributing to Alzheimer's disease by examining how various genetic variants interact within cellular networks. Using advanced techniques like molecular and epigenetic assays, the team aims to identify key interactions among genetic loci that may influence the development and progression of Alzheimer's. Patients may benefit from insights gained through the establishment of a novel interface that compiles and analyzes genetic and clinical data related to Alzheimer's disease. This comprehensive approach seeks to uncover the underlying mechanisms of Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without genetic predispositions to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease mechanisms, potentially guiding new treatment strategies.
How similar studies have performed: Previous research has shown promise in understanding genetic interactions in Alzheimer's disease, but this approach aims to provide a novel and comprehensive analysis.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.