Understanding how genetic changes happen in cells
The evolutionary and genomic drivers of mutation spectra
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11143026
This work explores why and how changes in our genetic code, called mutations, occur differently across various living things, with a focus on how this might relate to cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11143026 on ClinicalTrials.gov |
What this research studies
Our bodies are made of cells, and sometimes the DNA in these cells changes, leading to mutations. This project aims to understand why these changes happen in certain patterns and how they are influenced by evolution and the cell's environment. We are using yeast, a simple organism, to explore these fundamental processes, as yeast can help us learn about how mutations develop and are passed on. By studying yeast, we hope to uncover basic rules that apply to more complex organisms, including humans, and shed light on how these mutations contribute to diseases like cancer.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit future patients through a better understanding of disease mechanisms.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of the fundamental causes of mutations, which is crucial for developing new ways to prevent or treat cancers.
How similar studies have performed: This project builds upon existing ideas about mutation rates and evolution, aiming to confirm a controversial hypothesis using a novel approach to overcome previous limitations.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARP, NATHANIEL — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: SHARP, NATHANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers