Understanding how genetic changes and cell signals lead to leukemia
Synergistic role of signaling and epigenetics in leukemic transformation
This work explores how changes in our genes and cell communication pathways contribute to the development of leukemia, using samples from patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11138568 on NIH RePORTER |
What this research studies
We are looking closely at individual cells from patients with leukemia to understand how genetic changes and cell development work together to cause the disease. Our goal is to create models that show how these changes happen over time, helping us find important gene networks and new ways to treat leukemia. We also want to understand how different cell types interact in both healthy blood and leukemia, and how these interactions affect how well treatments work. This deeper understanding could lead to more effective therapies for patients.
Who could benefit from this research
Good fit: This foundational work is for patients with leukemia whose samples may contribute to understanding the disease at a cellular level.
Not a fit: Patients not diagnosed with leukemia or related blood cancers would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could uncover new ways to target and treat leukemia by understanding the core mechanisms that drive its development and resistance to therapy.
How similar studies have performed: While the specific approach of combining single-cell studies with innovative models for sequential mutational activation is cutting-edge, similar research into genetic and cellular mechanisms has led to advancements in cancer treatment.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Levine, Ross L — Sloan-Kettering Inst Can Research
- Study coordinator: Levine, Ross L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.