Understanding how genetic changes affect lung cell function in pulmonary fibrosis
Project 3: Functional Genomic Mechanisms of Epithelial Dysfunction in Pulmonary Fibrosis
['FUNDING_P01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10846187
This study is looking at how the lungs change in people with late-stage pulmonary fibrosis to find out how certain genes might affect lung cell health, and it’s for those who have a family history of this condition to help spot early signs of the disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10846187 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular and genetic changes that occur in the lungs of patients with late-stage pulmonary fibrosis (PF). By using advanced techniques like single-cell RNA sequencing, the team aims to identify how specific genetic variations influence the development of lung cell dysfunction. The study will analyze biopsy samples from individuals at risk for familial pulmonary fibrosis to uncover early signs of disease progression. This approach could lead to a better understanding of the mechanisms behind PF and potentially identify new targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of pulmonary fibrosis or those showing early signs of lung dysfunction.
Not a fit: Patients with advanced pulmonary fibrosis who are not part of the familial risk group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for pulmonary fibrosis.
How similar studies have performed: Other research has shown promising results using similar genomic approaches to understand lung diseases, indicating that this methodology has potential for success.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KROPSKI, JONATHAN ANDREW — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KROPSKI, JONATHAN ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.