Understanding how genetic changes affect lung cell function in pulmonary fibrosis
Official title: Project 3: Functional Genomic Mechanisms of Epithelial Dysfunction in Pulmonary Fibrosis
Funded at University of Michigan at Ann Arbor · NIH-10846187 · Data updated 2026-11-12
This study is looking at how the lungs change in people with late-stage pulmonary fibrosis to find out how certain genes might affect lung cell health, and it’s for those who have a family history of this condition to help spot early signs of the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $337,601 |
| NIH project number | 1P01HL172729-01 |
| Project ID | NIH-10846187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of pulmonary fibrosis or those showing early signs of lung dysfunction.
✕Less likely to help
Patients with advanced pulmonary fibrosis who are not part of the familial risk group may not benefit from this research.
What this research studies
This research investigates the cellular and genetic changes that occur in the lungs of patients with late-stage pulmonary fibrosis (PF). By using advanced techniques like single-cell RNA sequencing, the team aims to identify how specific genetic variations influence the development of lung cell dysfunction. The study will analyze biopsy samples from individuals at risk for familial pulmonary fibrosis to uncover early signs of disease progression. This approach could lead to a better understanding of the mechanisms behind PF and potentially identify new targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for pulmonary fibrosis.
How similar studies have gone: Other research has shown promising results using similar genomic approaches to understand lung diseases, indicating that this methodology has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kropski, Jonathan Andrew — University of Michigan at Ann Arbor
- Study coordinator: Kropski, Jonathan Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.