Understanding how genetic changes affect lung cancer growth and treatment response
Genetic Determinants of Tumor Growth and Drug Sensitivity in EGFR Mutant Lung Cancer
This study is looking at how certain genes affect tumor growth and treatment responses in people with EGFR mutant lung cancer, using a special mouse model to help find better ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10866512 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence tumor growth and sensitivity to treatments in patients with EGFR mutant lung cancer. By using a novel mouse model combined with advanced CRISPR technology, the study aims to identify how alterations in tumor suppressor genes interact with EGFR mutations. This approach allows researchers to explore the genetic interactions in a living organism, providing insights that traditional methods cannot achieve. The ultimate goal is to improve treatment strategies for lung cancer patients by understanding the underlying genetic mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with EGFR mutant lung cancer who are seeking new treatment options.
Not a fit: Patients with lung cancer that does not involve EGFR mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer patients with EGFR mutations, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in using CRISPR technology to explore genetic interactions in cancer, indicating that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Politi, Katerina Abigail — Yale University
- Study coordinator: Politi, Katerina Abigail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.