Understanding how genetic changes affect immune responses in squamous cell carcinoma

Who could benefit from this research

What this research studies

This research investigates the genetic factors that contribute to immune evasion in squamous cell carcinoma (SCC), a type of cancer that can occur in various parts of the body such as the skin and oral cavity. The study focuses on specific mutations in the PIK3CA gene, which may lead to the development of immune-resistant tumor-initiating cells. By examining how these mutations influence the behavior of cancer cells, the research aims to improve the effectiveness of immunotherapy treatments for patients with SCC. Patients may be involved in the research to help identify genetic markers that predict treatment responses.

Why it matters

Where this research is happening

• University of Chicago
  Chicago, United States Active

Researchers

• Principal investigator: Nicholson, Benjamin — University of Chicago
• Study coordinator: Nicholson, Benjamin

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.