Understanding how genetic changes affect heart muscle function
Structural and functional basis of myocardial dysregulation in genetic cardiomyopathy
['FUNDING_R01'] · LOYOLA UNIVERSITY CHICAGO · NIH-11112530
This study is looking at how certain genes affect the heart muscle cells that help your heart pump, using pig hearts to find out more about heart conditions like cardiomyopathy, with the hope of discovering new treatments to help people with heart issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-11112530 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variants impact the structure and function of heart muscle cells, specifically focusing on the sarcomere, which is crucial for heart contraction. Using advanced techniques like synchrotron X-ray diffraction, the study will analyze live cardiac muscle from a pig model, which closely resembles human hearts. The research aims to uncover the molecular details of how these genetic changes lead to cardiomyopathy, potentially paving the way for new treatments. By examining protein modifications and isoform switching, the team will gain insights into the regulation of heart muscle function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with genetic cardiomyopathies or those with a family history of such conditions.
Not a fit: Patients with non-genetic forms of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients with genetic cardiomyopathies.
How similar studies have performed: Previous research has shown promise in understanding cardiac function through similar approaches, but this study aims to provide novel insights using advanced techniques.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIRK, JONATHAN A — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: KIRK, JONATHAN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.