Understanding how genetic changes affect evolution and adaptation
Reinventing dN/dS and the study of natural selection
This study is looking at how different genetic changes affect evolution and natural selection, which could help us understand how species adapt and develop, and it might also lead to better personalized treatments for patients based on their unique genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11052626 on NIH RePORTER |
What this research studies
This research investigates the role of genetic variations, specifically synonymous and nonsynonymous changes, in natural selection and evolution. By developing new evolutionary models, the study aims to differentiate between genetic changes that are neutral and those that are influenced by selection. This approach will help researchers better understand the mechanisms of adaptation and the formation of new species. Patients may benefit from insights gained about genetic variations that could inform personalized medicine and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic variations that may influence their health or response to treatments.
Not a fit: Patients with no significant genetic variations or those not affected by genetic factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing adaptation, potentially leading to improved personalized treatment options.
How similar studies have performed: Other research has shown success in using evolutionary models to understand genetic variation, making this approach promising yet innovative.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hey, Emanuel — Temple Univ of the Commonwealth
- Study coordinator: Hey, Emanuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.