Understanding how genetic changes affect cell growth and drug resistance
Mapping genetic variation in enzyme velocity to growth rate phenotype
This study looks at how different levels of certain enzymes in E. coli affect how quickly the bacteria grow, and it aims to use this information to help find new antibiotics and understand how bacteria become resistant to them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10881154 on NIH RePORTER |
What this research studies
This research investigates how variations in metabolic enzyme activity and abundance influence the growth rates of cells, particularly focusing on E. coli. By creating a genome-scale model, the researchers aim to link gene expression to growth rate phenotypes under various conditions. The approach involves quantifying the effects of changes in gene expression and environmental factors on cell growth, using machine learning to predict outcomes. This could lead to advancements in antibiotic discovery and understanding drug resistance mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metabolic diseases or antibiotic resistance.
Not a fit: Patients with unrelated health conditions or those not affected by metabolic diseases or antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for antibiotic development and improved treatments for metabolic diseases.
How similar studies have performed: Other research has shown promise in using machine learning to model biological processes, indicating potential success for this approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Reynolds, Kimberly Ann — Ut Southwestern Medical Center
- Study coordinator: Reynolds, Kimberly Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.