Understanding how genetic changes affect brain development in autism models
Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologies
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10875454
This study is looking at how genes and the environment affect brain development in mice with autism, hoping to uncover important clues about how autism happens and how it might be treated.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10875454 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of genetic and environmental factors on brain development in mouse models of autism. By using advanced genomic barcoding technologies, the study aims to create a detailed map of how neural progenitor cells proliferate and differentiate during embryogenesis. This approach allows researchers to trace the lineage of cells and identify differences between typical and atypical development. The findings could provide insights into the mechanisms behind autism and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old diagnosed with autism spectrum disorder (ASD).
Not a fit: Patients who are over 21 years old or do not have a diagnosis of autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of autism's biological underpinnings, potentially informing new treatment strategies.
How similar studies have performed: Previous research using genomic barcoding technologies has shown promise in understanding developmental processes, suggesting potential success for this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALHOR, REZA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: KALHOR, REZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder