Understanding how genetic changes affect blood vessel formation in a specific condition.
Official title: EVALUATING THE IMPACT OF LOSS OF HETEROZYGOSITY ON LOCALIZED AVM FORMATION IN HHT
Funded at Tulane University of Louisiana · NIH-11074033 · Data updated 2026-11-12
This study is looking at how certain genes can cause problems with blood vessel formation in people with Hereditary Hemorrhagic Telangiectasia (HHT), and by using a mouse model, researchers hope to understand these issues better to find new treatments for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL174077-02 |
| Project ID | NIH-11074033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Hereditary Hemorrhagic Telangiectasia who may be experiencing symptoms related to abnormal blood vessel formation.
✕Less likely to help
Patients without a diagnosis of Hereditary Hemorrhagic Telangiectasia or those who do not exhibit symptoms related to blood vessel malformations may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to the formation of abnormal blood vessels in individuals with Hereditary Hemorrhagic Telangiectasia (HHT). It focuses on how the loss of certain genetic functions can lead to localized arteriovenous malformations (AVMs) that can cause serious health issues like bleeding and anemia. By developing a mouse model, the researchers aim to explore the mechanisms behind these genetic changes and their impact on blood vessel organization. This could provide insights into potential treatments for patients suffering from HHT.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or preventing complications associated with HHT.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in blood vessel disorders, indicating that this approach may yield valuable insights.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Guidroz, Adella Patience Boudreaux — Tulane University of Louisiana
- Study coordinator: Guidroz, Adella Patience Boudreaux
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.