Understanding how genetic changes affect acute myeloid leukemia
Dissecting the role of clonal evolution in NPM1-mutant AML
['FUNDING_OTHER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10893531
This study is looking at how the genes of acute myeloid leukemia (AML) change over time to help find new treatments that could work better for patients, using advanced tools to understand the disease better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10893531 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic evolution of acute myeloid leukemia (AML) by creating models that mimic the disease's progression. Using advanced techniques like CRISPR for gene editing and single-cell DNA sequencing, the researchers aim to identify critical molecular dependencies that could lead to new treatment options. By analyzing how these genetic changes influence the behavior of leukemia cells, the study seeks to uncover potential therapeutic targets that could improve patient outcomes. Patients may benefit from insights gained through this research, which could lead to more effective therapies tailored to their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with NPM1-mutant acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those without NPM1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promise in using genetic models to understand cancer evolution, suggesting that this approach could yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILES, LINDE A — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: MILES, LINDE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers