Understanding how genetic background and HIV affect liver disease progression and treatment response
Evaluating the impact of genetic ancestry and HIV on cirrhosis progression and response to statin therapy among a diverse multi-ethnic cohort of patients with cirrhosis
['FUNDING_U01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10909028
This study is looking at how your genetic background and HIV status can affect liver disease and how well statin medications work for you, and it's designed for a diverse group of patients to help us understand different experiences with liver health.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10909028 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic ancestry and HIV status influence the progression of cirrhosis and the effectiveness of statin therapy in a diverse group of patients. By focusing on a multi-ethnic cohort, the study aims to uncover disparities in liver disease outcomes that may be linked to biological, cultural, and socioeconomic factors. Patients will be monitored over time to assess how their genetic makeup and HIV infection impact their liver health and response to treatment. The study employs a prospective approach, collecting genetic data alongside clinical information to provide a comprehensive understanding of these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cirrhosis, particularly those who are HIV-positive or belong to diverse racial and ethnic backgrounds.
Not a fit: Patients without cirrhosis or those who do not have HIV may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with cirrhosis, improving their health outcomes.
How similar studies have performed: Previous research has shown that understanding genetic factors can significantly impact treatment outcomes in various diseases, suggesting potential success for this approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDBERG, DAVID SETH — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: GOLDBERG, DAVID SETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Alcoholic Liver Diseases