Understanding how genetic and brain factors influence depression in children at risk.
Hippocampal and Genetic Mechanisms Underlying Development of Depression in Children at High Family Risk
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10949633
This study is looking at why some kids with a family history of depression end up struggling with it while others don’t, by exploring how their brains, genes, and surroundings play a role, so we can better help those who might be at risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10949633 on ClinicalTrials.gov |
What this research studies
This research investigates why some children with a family history of depression develop the disorder while others do not. It aims to identify the neurobiological, genetic, and environmental factors that contribute to either vulnerability or resilience in these children. By studying brain structures and genetic markers, the research seeks to uncover how these elements interact to influence mental health outcomes. The findings could lead to better identification of at-risk children and the development of targeted interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have a family history of depression or related mood disorders.
Not a fit: Children without any family history of depression or those who are already diagnosed with severe mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying children at high risk for depression and developing effective prevention strategies.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and neurobiological underpinnings of depression, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN DIJK, MILENNA TAMARA — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: VAN DIJK, MILENNA TAMARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders