Understanding How Genes Work Inside Our Cells' Powerhouses
Flow Of Gene Expression Across Mitochondrial Condensates
['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11176235
This research explores how genes are organized and become active within mitochondria, the tiny powerhouses inside our cells, to understand how this process affects our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11176235 on ClinicalTrials.gov |
What this research studies
This project aims to understand the intricate organization of genetic material within mitochondria, which are vital for cell energy. Researchers are looking at how specific molecules come together to form structures called 'condensates' inside mitochondria, where genes are stored and activated. They will use advanced microscopy and theoretical models to identify the interactions that create these structures and observe their behavior. The goal is to uncover how disruptions in these processes might lead to mitochondrial problems and disease.
Who could benefit from this research
Good fit: This foundational biology project does not directly involve patient participation, but future studies building on this knowledge could benefit individuals with mitochondrial diseases.
Not a fit: Patients seeking immediate treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal fundamental mechanisms of mitochondrial function, potentially leading to new ways to understand and address diseases linked to mitochondrial dysfunction.
How similar studies have performed: The concept of phase transitions in gene regulation is an emerging field, and while some aspects are understood in other cellular compartments, its application to mitochondrial gene expression is a novel and less explored area.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERIC, MARINA — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: FERIC, MARINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease