Understanding how genes work inside individual cells
Revealing cell-level gene regulation through integration of single-cell multi-omics measurements
This project aims to create new computer tools to help us see how genes are controlled in each cell, which can help us understand diseases better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11174271 on NIH RePORTER |
What this research studies
Researchers are building advanced computer programs to make sense of complex genetic information from individual cells. These programs will help combine different types of cell data to get a clearer picture of how genes are turned on and off. By doing this, we can learn more about the tiny details of gene control, including how distant parts of DNA affect gene activity and how messages from genes are processed. This deeper understanding is crucial for finding new ways to diagnose, treat, and prevent illnesses.
Who could benefit from this research
Good fit: This foundational computational work does not directly involve patient participation, but future applications may benefit individuals with various diseases.
Not a fit: Patients seeking immediate clinical interventions or direct treatment will not receive benefit from this foundational computational methodology development.
Why it matters
Potential benefit: If successful, this work could provide a fundamental understanding of gene regulation at the cellular level, paving the way for new approaches to disease diagnosis, treatment, and prevention.
How similar studies have performed: While single-cell sequencing is an established technique, the development of new computational methods to integrate multi-omics data at this resolution is an active and evolving area of research.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Wang, Yijie — Trustees of Indiana University
- Study coordinator: Wang, Yijie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.