Understanding how genes work in our tissues
Tissue biology studies of histone modification, nascent transcription, and post-transcription regulation
This research explores how our genes are controlled in body tissues to help them develop and repair themselves.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11136493 on NIH RePORTER |
What this research studies
Our bodies are constantly developing and repairing, and this process relies on how genes are turned on and off. This project looks closely at how genes are regulated at the level of messenger RNA (mRNA), which carries instructions from our DNA. Using skin as a model, we aim to understand how cells control gene activity and how this changes as stem cells activate and differentiate. This work will help us learn more about the basic mechanisms that keep our tissues healthy and allow them to regenerate.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone interested in the basic biological processes of tissue development and regeneration, though direct patient participation is not currently part of this specific grant.
Not a fit: Patients seeking immediate new treatments or clinical interventions would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide fundamental knowledge about how tissues develop and regenerate, potentially leading to new ways to address tissue repair or disease in the future.
How similar studies have performed: The abstract indicates that understanding these specific regulatory mechanisms in living tissues is currently poorly understood, suggesting this approach is novel or addresses a gap in knowledge.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Tumbar, Tudorita — Cornell University
- Study coordinator: Tumbar, Tudorita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.