Understanding how genes turn on in cancer
Single-molecule analysis of eukaryotic transcription activation
This project aims to understand how genes are switched on in cells, a process that often goes wrong in cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11136996 on NIH RePORTER |
What this research studies
Our cells have a complex system for turning genes on and off, and when this system malfunctions, it can contribute to diseases like cancer. This project uses advanced microscopy to watch, at a very tiny scale, how the machinery that turns on genes interacts with DNA. By studying these interactions in detail, we hope to uncover the fundamental steps that lead to gene activation, especially focusing on processes that are abnormal in cancer cells. We use a model system involving yeast extracts to precisely measure how different components work together to switch genes on.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical applications could benefit individuals with various types of cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how cancer develops and potentially identify new targets for future cancer treatments.
How similar studies have performed: This project builds upon previous work by the researchers, extending our understanding of gene activation mechanisms.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Buratowski, Stephen — Harvard Medical School
- Study coordinator: Buratowski, Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.