Understanding how genes switch on and off in human cells
Official title: Probing co-transcriptional gene regulatory logics in human transcriptomes
Funded at Boston University (Charles River Campus) · NIH-11380772 · Data updated 2026-11-12
Aims to map how gene transcription and RNA processing work together in human cells to control which messages get made.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $412,500 |
| NIH project number | 5R35GM147254-05 |
| Project ID | NIH-11380772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly a patient-involved study; findings could inform future research that benefits patients with gene-regulation-related conditions.
✕Less likely to help
No direct patient involvement in this grant.
What this research studies
This project will study how transcription and RNA splicing influence each other in human genes. Researchers will use a combination of genetic, molecular, and computational approaches to uncover the mechanisms that couple transcription with RNA processing. The results could reveal new ways that cells regulate gene expression in health and disease and may point to targets for future therapies. The work will involve high-throughput data analyses to connect promoter activity, splicing decisions, and transcript outcomes.
Why it matters
Potential benefit: Better understanding of gene regulation could lead to new ideas for treating diseases where gene expression goes awry.
How similar studies have gone: Previous work has shown that transcription and splicing are interconnected, with emerging evidence supporting this coupling approach.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Fiszbein, Ana — Boston University (Charles River Campus)
- Study coordinator: Fiszbein, Ana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.