Understanding how genes shape physical traits in organisms
The gene regulatory basis of the genotype-phenotype map
This study looks at how genes shape the physical features of fruit flies to help us understand how traits develop and change over time, which could give us helpful insights into genetics and health for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11080384 on NIH RePORTER |
What this research studies
This research investigates the genetic basis of how physical traits develop and evolve in organisms, using the fruit fly Drosophila as a model. It focuses on gene regulatory networks that control the expression of genes during development, which ultimately influences the morphology of the organism. By examining how these networks function and evolve, the research aims to uncover the mechanisms behind the emergence of new traits and how mutations can affect these processes. Patients may benefit from insights gained about genetic influences on development and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions that affect physical development or morphology.
Not a fit: Patients with conditions unrelated to genetic regulation of physical traits may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors that contribute to physical traits and diseases in humans.
How similar studies have performed: Previous research has shown success in understanding gene regulatory networks in model organisms, suggesting potential for breakthroughs in related areas.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Rebeiz, Mark J — University of Pittsburgh at Pittsburgh
- Study coordinator: Rebeiz, Mark J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.