Understanding how genes, metabolism, and gut bacteria affect childhood asthma
Integrating the genome, metabolome, and microbiome for childhood asthma: Risk and endotypes
This study is looking at how a child's genes, metabolism, and gut bacteria work together to help us understand why some kids develop asthma, especially after having bronchiolitis, and it involves collecting samples from infants to find ways to prevent asthma in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11044073 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between a child's genetics, metabolism, and microbiome to better understand the development of asthma in children. By analyzing data from a large cohort of infants who experienced bronchiolitis, the study aims to identify specific biological markers and mechanisms that contribute to asthma risk and its various forms. Participants will provide biospecimens, including blood and airway samples, which will be analyzed using advanced sequencing techniques. The goal is to uncover insights that could lead to effective prevention strategies for childhood asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years, particularly those with a history of bronchiolitis or asthma symptoms.
Not a fit: Patients who do not have a history of respiratory issues or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and personalized treatments for childhood asthma.
How similar studies have performed: Previous studies have shown promise in understanding asthma through similar integrative approaches, suggesting potential for success in this research.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zhu, Zhaozhong — Massachusetts General Hospital
- Study coordinator: Zhu, Zhaozhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.