Understanding how genes linked to Alzheimer's disease affect brain function
Elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes
This study is looking at how specific genes might affect the development of Alzheimer's disease, using advanced tools to understand their impact on brain cells from patients, with the hope of finding better ways to predict and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10538968 on NIH RePORTER |
What this research studies
This research investigates the complex genetics of Alzheimer's disease, particularly how certain risk genes and genetic variants influence the disease's development and related brain functions. By using advanced techniques like CRISPR and single-cell RNA sequencing, the study aims to identify the biological effects of these genes in brain cells derived from patients. The goal is to create a detailed understanding of how these genetic factors contribute to Alzheimer's disease, which could lead to improved risk prediction and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who are at risk due to genetic factors.
Not a fit: Patients who do not have any genetic predisposition to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Alzheimer's disease, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding genetic contributions to Alzheimer's disease, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Shen, Yin — University of California, San Francisco
- Study coordinator: Shen, Yin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.