Understanding how genes linked to Alzheimer's affect blood vessel function
Official title: Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions
Funded at Regenerative Research Foundation · NIH-10873179 · Data updated 2026-11-12
This study is looking at how certain genes linked to Alzheimer's Disease affect the blood vessels in the brain, which could help us understand why some people experience memory problems, and it might lead to new ways to treat the disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regenerative Research Foundation NIH-funded |
| Lab location | 1 site (Albany, UNITED STATES) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,573,956 |
| NIH project number | 5U01AG072464-04 |
| Project ID | NIH-10873179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's Disease, particularly those with a family history or genetic predisposition.
✕Less likely to help
Patients with non-Alzheimer's related cognitive impairments or those without any genetic risk factors for Alzheimer's may not benefit from this research.
What this research studies
This research investigates the role of specific genes associated with Alzheimer's Disease in the functioning of blood vessels in the brain. By examining how these genes impact vascular cells, the study aims to uncover their contribution to cerebrovascular problems that may lead to cognitive decline. The research employs advanced techniques such as CRISPR gene editing and various models to analyze the effects of these genes on blood flow and inflammation in the brain. The findings could provide insights into new therapeutic approaches for Alzheimer's Disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and potentially slow down cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between vascular health and Alzheimer's Disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Regenerative Research Foundation
Albany, United States Active
Researchers
- Principal investigator: Temple, Sally — Regenerative Research Foundation
- Study coordinator: Temple, Sally
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.