Understanding how genes like p53 control cell growth in cancer
Dissecting the Dynamic Interplay Between, p53, Chromatin and Transcriptional Bursting in Single Cells
This project explores how genes turn on and off in cells, especially focusing on how this process goes wrong in cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11136498 on NIH RePORTER |
What this research studies
Our cells have genes that switch on and off in short bursts, like a light flickering. This 'bursting' helps cells remember past signals, a process called transcriptional memory. When this memory or the gene switching goes awry, it can contribute to diseases like cancer. This work uses advanced imaging to watch these gene activities in real-time, helping us understand how genes like p53, a key player in cancer, are controlled.
Who could benefit from this research
Good fit: Patients with various types of cancer could potentially benefit from future treatments developed from this fundamental understanding of gene regulation.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new ways to target the faulty gene control mechanisms that drive cancer growth.
How similar studies have performed: This project builds upon existing knowledge and preliminary findings, while also exploring novel aspects of gene regulation and transcriptional memory.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Coleman, Robert — Albert Einstein College of Medicine
- Study coordinator: Coleman, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.