Understanding how genes interact with their regulatory elements in 3D space
Genetic and Epigenetic Controls of Enhancer-Promoter Interactions
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-10842795
This study is looking at how certain parts of our DNA, called enhancers, help control genes from a distance, which is important for understanding how our bodies develop and how some cancers happen, so that patients can gain insights into the genetic reasons behind these issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10842795 on ClinicalTrials.gov |
What this research studies
This research investigates how genes are regulated by enhancers that can be located far away from the genes they control, particularly in the context of embryonic development and cancer. By examining the 3D structure of the genome, the study aims to uncover the mechanisms that dictate how these enhancers and promoters interact. The research employs advanced genomic tools to analyze the genetic sequences and structural features that influence these interactions, which are crucial for proper gene expression. Patients may benefit from insights gained into the genetic causes of developmental abnormalities and cancers linked to these regulatory mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with developmental abnormalities or cancers that may be linked to genetic regulatory disruptions.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by developmental abnormalities or cancers may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating developmental disorders and cancers by targeting the underlying genetic regulatory mechanisms.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through 3D genome architecture, indicating that this approach has potential for significant discoveries.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPITZ, FRANCOIS — UNIVERSITY OF CHICAGO
- Study coordinator: SPITZ, FRANCOIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers