Understanding how genes interact to influence health and disease
Systems genomics of complex traits
This study is looking at how our genes and the environment work together to affect our health, using tiny worms to see how different genetic changes can impact things like how well our bodies handle stress, so we can better understand what influences our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11011847 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between genes and their environments that affect human health and disease. Using advanced genomic engineering techniques and the model organism Caenorhabditis elegans, researchers will manipulate and trace individual genetic lineages to assess the impact of various genetic mutations. The study aims to analyze genetic variation and its effects on traits such as oxidative stress resistance, providing insights into how these interactions shape health outcomes. By integrating genomic data with functional testing, the research seeks to create a comprehensive understanding of genetic influences on complex traits.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic disorders or those interested in understanding the genetic basis of their health conditions.
Not a fit: Patients with purely environmental health issues unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic factors that contribute to human diseases, potentially informing better prevention and treatment strategies.
How similar studies have performed: Previous research has shown promise in using genomic approaches to understand complex traits, indicating that this methodology could yield valuable insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Phillips, Patrick C. — University of Oregon
- Study coordinator: Phillips, Patrick C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.