Understanding how genes influence the growth of the human brain's outer layer.
Modeling gene regulatory mechanisms contributing to the evolution of the human cerebral cortex
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-10917075
This study is looking at how certain genetic changes that are unique to humans help shape our brains, especially in ways that might relate to conditions like autism, so we can better understand how these changes affect brain development and cognitive abilities.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10917075 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mechanisms that contribute to the development of the human cerebral cortex, which is crucial for higher cognitive functions. By examining specific genetic changes unique to humans, the study aims to uncover how these changes affect brain development and may relate to neurodevelopmental disorders like autism. The approach involves analyzing Human Accelerated Regions (HARs) that play a role in regulating gene activity during brain development. This research could provide insights into the biological underpinnings of cognitive impairments associated with these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those under 21 years old, who may benefit from insights into the genetic basis of their conditions.
Not a fit: Patients with neurodevelopmental disorders not related to genetic factors or those over 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in neurodevelopmental disorders, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown promise in understanding gene regulatory mechanisms in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAUMGARTNER, MARY — YALE UNIVERSITY
- Study coordinator: BAUMGARTNER, MARY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder