Understanding how genes influence sex ratios in fruit flies
Investigating the evolutionary genetics and genomic consequences of sex-ratio meiotic drive in Drosophila
This research explores how certain genes in fruit flies can affect the balance of male and female offspring, and what this means for their reproduction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11112516 on NIH RePORTER |
What this research studies
Our bodies contain tiny genetic elements that sometimes try to get passed on more often than others, even if it's not always good for the organism. This project looks at how these "selfish" genes on sex chromosomes in fruit flies can lead to an imbalance in male and female offspring by affecting sperm. We want to understand the genetic battles that happen when these genes try to take over, and how the flies' bodies try to fight back. This helps us learn about the fundamental rules of genetics and reproduction.
Who could benefit from this research
Good fit: Patients experiencing unexplained infertility or those interested in the fundamental genetic causes of reproductive imbalances might find this basic research relevant to future advancements.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions will not find direct benefit from this foundational genetic research.
Why it matters
Potential benefit: Understanding these basic genetic conflicts in reproduction could one day offer insights into unexplained infertility or reproductive challenges in humans.
How similar studies have performed: Previous work by this team has already identified key aspects of these genetic conflicts and their rapid evolution in closely related fruit fly species.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Presgraves, Daven C — University of Rochester
- Study coordinator: Presgraves, Daven C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.