Understanding how genes influence decision-making and opioid use in rats
Genomic mechanisms of decision-making and opioid use trajectories in the rat
This study is looking at how genes might affect the way rats move from using opioids to becoming addicted, helping us understand the biological reasons behind opioid use disorder.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10899676 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that may influence how rats transition from opioid use to abuse and dependence. By examining the neurobiology of different decision-making behaviors associated with drug use, the study aims to identify distinct genetic pathways that govern these behaviors. The researchers utilize advanced techniques like ATAC sequencing to analyze chromatin accessibility and its relation to opioid use trajectories. This approach allows for a deeper understanding of the biological factors that contribute to opioid use disorder.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with a history of opioid use or those at risk of developing opioid use disorder.
Not a fit: Patients who do not have a history of opioid use or are not at risk for opioid use disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors influencing opioid use disorder, potentially informing treatment strategies for patients.
How similar studies have performed: While this research explores novel genetic mechanisms in opioid use, similar studies have shown promise in understanding the biological underpinnings of addiction.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dileone, Ralph J — Yale University
- Study coordinator: Dileone, Ralph J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.