Understanding how genes influence cell behavior using advanced imaging techniques
Unraveling the genetic basis of cellular behaviors with deep learning and imaging-based reverse genetics
This study is exploring how our cells act and change by using cool imaging techniques and smart computer tools, and it's designed for scientists who want to better understand both healthy and diseased tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10472362 on NIH RePORTER |
What this research studies
This research investigates the genetic basis of how cells behave by utilizing advanced imaging technologies and deep learning methods. It aims to measure various aspects of cellular behavior, such as shape and gene expression, in both normal and diseased tissues. By combining live-cell imaging with spatial genomics, the project seeks to create a comprehensive understanding of cellular dynamics. The goal is to make these innovative methods accessible to the broader life sciences community, enhancing our ability to analyze cellular images and biological networks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve significant cellular behavior changes, such as cancer or genetic disorders.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular behavior changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cellular behaviors, potentially informing new treatments for various diseases.
How similar studies have performed: Other research has shown promise in using imaging and genomics together, but this approach aims to innovate further in the field, making it a novel endeavor.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Van Valen, David a — California Institute of Technology
- Study coordinator: Van Valen, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.