Understanding how genes influence brain networks in Alzheimer's disease
Integrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY · NIH-10361057
This study is looking at how our genes might influence brain function in people with Alzheimer's disease, using a lot of data to help us understand the connections between genetics and brain health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10361057 on ClinicalTrials.gov |
What this research studies
This research investigates the connections between genetic factors and brain network functions in individuals with Alzheimer's disease. By integrating large datasets from neuroimaging and genomic studies, the team aims to uncover how genetic expression affects brain structure and connectivity. The approach combines advanced statistical methods with expertise in network neuroscience and cognitive aging to analyze data from thousands of individuals. This comprehensive analysis could lead to new insights into the biological mechanisms underlying Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients who are not diagnosed with Alzheimer's disease or related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown success in linking genetic factors to brain function, suggesting that this integrative approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUBINOV, MIKAIL — VANDERBILT UNIVERSITY
- Study coordinator: RUBINOV, MIKAIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia