Understanding how genes for vision are regulated in the eye's light-sensing cells
Official title: Molecular mechanisms of transcriptional regulation of phototransduction genes in mammalian rod photoreceptors
Funded at Stanford University · NIH-11084580 · Data updated 2026-11-12
This study is looking at how certain genes work in the eye to help us see in low light, and it aims to find out how problems with these genes might cause vision loss, which could help develop new treatments for people with retinal diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00EY030918-02 |
| Project ID | NIH-11084580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with retinal degeneration or those at risk for vision loss due to genetic factors.
✕Less likely to help
Patients with retinal conditions unrelated to phototransduction gene regulation may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that control the expression of genes involved in phototransduction, the process by which light is converted into electrical signals in the retina. By focusing on rod photoreceptors, which are crucial for low-light vision, the study aims to uncover how defects in gene regulation can lead to retinal diseases and blindness. The approach involves analyzing the splicing of mRNA, a critical step in gene expression, to understand how variations can affect the production of proteins necessary for vision. Patients may benefit from insights gained into the genetic causes of retinal degeneration, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for retinal diseases that cause blindness.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in other contexts, suggesting potential for success in this area as well.
Where this research is happening
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Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Corso-Diaz, Elsa Ximena — Stanford University
- Study coordinator: Corso-Diaz, Elsa Ximena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.