Understanding how genes fold in the brain related to smell and Alzheimer's disease
Interrogating genome folding trajectories in health and disease
This study is looking at how genes that help us smell work together and how these interactions might change in people with Alzheimer's disease, so we can better understand how their sense of smell is affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911096 on NIH RePORTER |
What this research studies
This research investigates the complex interactions of genes responsible for our sense of smell and how these interactions may change in conditions like Alzheimer's disease. By using advanced techniques to track the development of olfactory sensory neurons, the study aims to map out how specific genes are activated during this process. The researchers will employ innovative methods to visualize these genetic interactions at a single-cell level, providing insights into the normal and disrupted gene folding trajectories in health and disease. This could lead to a better understanding of how olfactory functions are affected in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease or those experiencing olfactory dysfunction.
Not a fit: Patients without any olfactory issues or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's disease and potentially lead to new therapeutic strategies targeting olfactory dysfunction.
How similar studies have performed: While the specific approach of mapping gene folding in olfactory neurons is novel, similar studies have shown success in understanding genetic interactions in other contexts.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Lomvardas, Stavros — Columbia University Health Sciences
- Study coordinator: Lomvardas, Stavros
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.