Understanding how genes control tooth enamel formation
Genomic and functional investigations of the transcriptional regulatory network of tooth enamel development
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-11125851
This project looks at the genetic instructions that guide healthy tooth enamel development to better understand and help infants born with dental problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-11125851 on ClinicalTrials.gov |
What this research studies
Many infants are born with dental issues like missing teeth, malformed teeth, or weak enamel. This work aims to uncover the specific genetic and cellular processes that build strong tooth enamel. Researchers are focusing on a key gene called p63, which is known to be involved in conditions like ectodermal dysplasia that affect teeth. By using advanced genetic models, they hope to learn how p63 influences tooth development and why its mutations lead to dental anomalies.
Who could benefit from this research
Good fit: This foundational research is relevant to infants and children affected by congenital dental anomalies, such as enamel dysplasia, tooth agenesis, or malformation.
Not a fit: Patients without congenital dental anomalies or those whose conditions are not related to early tooth development may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new therapies and treatments for congenital dental disorders, improving oral health for many children.
How similar studies have performed: While the specific role of ΔNp63 in tooth development is not fully understood, previous research has established p63 as a master regulator of ectodermal development, suggesting a strong foundation for this approach.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KWON, HYUK JAE EDWARD — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: KWON, HYUK JAE EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.