Understanding how genes control tooth enamel development
Official title: Genomic and functional investigations of the transcriptional regulatory network of tooth enamel development
Funded at State University of New York at Buffalo · NIH-10872170 · Data updated 2026-11-12
This study is looking at how certain genes affect the growth of tooth enamel, which is important for keeping our teeth healthy, and it aims to find new ways to help babies who have problems with their teeth because of genetic issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $617,293 |
| NIH project number | 5R01DE033085-02 |
| Project ID | NIH-10872170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and children with congenital dental anomalies, particularly those with enamel dysplasia or related conditions.
✕Less likely to help
Patients without any dental anomalies or those whose conditions are unrelated to genetic factors may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms that regulate the development of tooth enamel, which is crucial for oral health. By focusing on the role of specific transcription factors, particularly the p63 gene, the study aims to uncover why certain genetic mutations lead to dental anomalies such as enamel dysplasia. Using a specialized mouse model, researchers will analyze how these genetic factors influence tooth development and identify potential therapeutic targets for congenital dental disorders. This work could lead to new treatments for infants born with tooth development issues.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for congenital dental anomalies, improving oral health outcomes for affected individuals.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in tooth development, but this specific approach using the p63 gene is relatively novel.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Kwon, Hyuk Jae Edward — State University of New York at Buffalo
- Study coordinator: Kwon, Hyuk Jae Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.