Understanding how genes control the growth and development of placenta cells
Deciphering gene regulatory networks modulating human trophoblast stem cell self-renewal and differentiation
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-11040311
This study is looking at how certain genes help stem cells that form the placenta grow and change, which could help us understand why some pregnancies don't go as planned and improve our knowledge of how the placenta works.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-11040311 on ClinicalTrials.gov |
What this research studies
This research investigates the gene regulatory networks that influence the self-renewal and differentiation of human trophoblast stem cells, which are crucial for proper placenta development. By using advanced molecular biology techniques, the study aims to identify key transcription factors and their interactions that govern the behavior of these cells. The findings could provide insights into the causes of early pregnancy failures and other related disorders, ultimately improving our understanding of placental biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early pregnancy complications or those interested in understanding placental health.
Not a fit: Patients who are not pregnant or those with established pregnancy complications unrelated to trophoblast function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for early pregnancy complications.
How similar studies have performed: Previous research has shown success in understanding gene regulation in other cell types, but this specific focus on human trophoblasts is relatively novel.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JONGHWAN — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: KIM, JONGHWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.