Understanding how genes control the development of the skull and face.
Genetic Regulatory Network in Craniofacial Development
['FUNDING_R01'] · ADA FORSYTH INSTITUTE, INC. · NIH-11048532
This study is looking at how certain genes help shape the skull and how problems with these genes can lead to conditions like craniosynostosis, which affects how the skull forms, with the hope of finding better treatments for people with craniofacial issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ADA FORSYTH INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11048532 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic signaling networks that govern craniofacial development, particularly focusing on the growth centers in the skull known as cranial sutures. By studying skeletal stem cells in these sutures, the research aims to uncover how defects in their development can lead to conditions like craniosynostosis, which affects skull formation. The approach includes analyzing the behavior of these stem cells and their role in bone healing and regeneration. Patients may benefit from insights that could lead to improved treatments for craniofacial abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with craniofacial abnormalities or those at risk for conditions like craniosynostosis.
Not a fit: Patients with craniofacial conditions unrelated to genetic signaling or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for craniofacial disorders, improving outcomes for affected individuals.
How similar studies have performed: Previous research has shown promise in understanding craniofacial development through genetic analysis, indicating that this approach may yield valuable insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- ADA FORSYTH INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSU, WEI — ADA FORSYTH INSTITUTE, INC.
- Study coordinator: HSU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.