Understanding how genes control the development of retinal cells
Official title: Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia
Funded at Johns Hopkins University · NIH-10871097 · Data updated 2026-11-12
This study is looking at how certain genes help eye cells develop, which could lead to new treatments for eye problems, and it's for anyone interested in understanding how our vision works and how we might fix it when things go wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $651,846 |
| NIH project number | 1R01EY036173-01 |
| Project ID | NIH-10871097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may be affected by retinal disorders or are interested in the genetic aspects of retinal development.
✕Less likely to help
Patients with retinal conditions unrelated to developmental processes or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the gene regulatory networks that influence the development of retinal progenitor cells, which are crucial for forming various types of retinal cells. By using advanced techniques like single-cell RNA sequencing and ATAC sequencing, the study aims to identify specific transcription factors that dictate whether these cells develop into early or late-stage retinal cells. The researchers will manipulate these transcription factors to observe changes in cell types and gene expression, providing insights into the mechanisms of retinal development and potential therapies for retinal disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for blindness and other retinal diseases by enhancing our understanding of retinal cell development.
How similar studies have gone: Previous research has shown promise in understanding gene regulatory networks in other developmental contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Blackshaw, Seth — Johns Hopkins University
- Study coordinator: Blackshaw, Seth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.