Understanding how genes control mammary gland development
Transcriptional regulation of mammary gland development
This study is looking at how certain proteins called E2F transcription factors help the mammary gland grow and work properly, which is important for breastfeeding, and it could also help us understand how problems with these proteins might be linked to breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11057616 on NIH RePORTER |
What this research studies
This research investigates the role of specific transcription factors in the development and function of the mammary gland, which is crucial for lactation and offspring rearing. The study focuses on the E2F transcription factors, particularly the repressor types, to understand their influence on mammary gland development. By using advanced techniques like chromatin immunoprecipitation coupled with sequencing (ChIP-seq), researchers aim to uncover how these factors regulate key developmental genes. Insights gained from this research could help explain how disruptions in these processes may lead to breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast cancer or those who are at high risk for developing breast cancer.
Not a fit: Patients who are not affected by breast cancer or do not have risk factors related to mammary gland development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating breast cancer by targeting the underlying mechanisms of mammary gland development.
How similar studies have performed: Other research has shown success in understanding the roles of transcription factors in cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Andrechek, Eran Robert — Michigan State University
- Study coordinator: Andrechek, Eran Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.